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Figure 6. Glycogen metabolism underlies memory consolidation. Glycogen, situated in astrocytes within the hippocampus, is metabolized to lactate, which is transported to the pre and postsynaptic terminals, the place it fulfils separate roles, being converted to glutamate in the presynaptic terminal, and aiding consolidation in the postsynaptic terminal. Recently it has been shown that neuronal exercise regulates many astrocytic genes, particularly up-regulation of genes related to glycolysis and lactate, however not oxidative metabolism. The dogmatic view of cellular expression of glycogen in the brain is that it is solely loctated in astrocytes in adults, and circulation booster is barely expressed in neurones throughout development (Bloom and Fawcett, 1968; Magistretti et al., 1993a) or because of pathology (Vilchez et al., 2007). However with age neurons present an increased capacity to metabolize glycogen and perform glycolysis, thereby demonstrating a shift from dependence to independence on astrocytic lactate (Drulis-Fajdasz et al., 2018). The explanations for this are unknown but could effectively have significance to an aging population.